Oligonucleotide therapeutics

Oligonucleotide Synthesis & Manufacturing

MayMag Biologics provides GMP-grade oligonucleotide synthesis services for antisense, siRNA, aptamer, and diagnostic applications — from sequence design through finished drug product.

Synthesis Capabilities

Antisense Oligonucleotides (ASO)

Synthesis of phosphorothioate, 2'-MOE, and LNA-modified ASOs for gene silencing and splice-switching applications. Full GMP documentation for IND-enabling studies.

Phosphorothioate2'-MOELNAGapmer design

siRNA & RNAi Therapeutics

Double-stranded siRNA synthesis with chemical modifications for enhanced stability and reduced immunogenicity. Supports lipid nanoparticle and GalNAc conjugate formulations.

2'-OMe2'-F modificationsGalNAc conjugationLNP-compatible

Aptamers

DNA and RNA aptamer synthesis for therapeutic and diagnostic applications. SELEX-derived sequences with optional PEGylation and conjugation to payloads or detection labels.

DNA aptamersRNA aptamersPEGylationConjugation-ready

Diagnostic Oligonucleotides

PCR primers, hybridisation probes, FISH probes, and NGS adaptors synthesised to research or GMP grade with fluorescent, biotin, or quencher modifications.

PCR primersFISH probesFluorescent labelsBiotin conjugates

Available Chemical Modifications

BackbonePhosphorothioate (PS), Phosphodiester (PO), Methylphosphonate

Sugar2'-OMe, 2'-F, 2'-MOE, LNA, cEt, UNA

5' / 3' LabelsFAM, TAMRA, Cy3, Cy5, BHQ1/2, Biotin, Cholesterol

ConjugatesGalNAc, PEG, Lipid, Antibody (custom)

InternucleotidePhosphorothioate, Boranophosphate

Quality Specifications

ScaleNanomole to gram scale

Purity≥ 85% (research), ≥ 95% (GMP)

PurificationRP-HPLC, IEX-HPLC, PAGE

AnalysisLC-MS, CGE, ICP-MS (residual metals)

DocumentationCoA, batch record, MS data, HPLC trace

Discuss your oligonucleotide programme

Our oligonucleotide scientists can advise on sequence design, modification strategy, and scale-up pathway.

Contact Our Scientists